“The knife has reached my bone.”

I've had all I can take.

Heard in the wild

از دست این همسایه‌ها کارد به استخونم رسیده.

I've had it up to here with these neighbours.

More exasperation

دود از کله‌اش بلند شد
dud az kallash boland shod
“Smoke rose from his head.”
He was completely flabbergasted (and sometimes fuming too).
مثل خر تو گل موندن
mesl-e khar tu gel mundan
“To be stuck like a donkey in the mud.”
To be hopelessly stuck, with no way forward or back.
مخمو خوردی
mokhamo khordi
“You've eaten my brain.”
You've talked my ear off, or nagged me senseless.
جونم به لبم رسید
junam be labam resid
“My soul has reached my lips.”
I'm at the end of my tether.